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Dear Madam or Sir,
The DIARECT team |
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系统性红斑狼疮(Systemic Lupus Erythematosus; SLE)是一种以免疫调节障碍为特征的自身免疫性疾病，会引起抗核抗体的产生、循环免疫复合物的再生，并且能激活补体系统。 抗Sm抗体是系统性红斑狼疮高特异性抗体，已记录于美国风湿病学院分类标准中。抗Sm抗体出现于5-30%的SLE患者中，这种差异取决于检测系统和针对 群组研究所选择的标准。研究同样指出抗Sm抗体的发病率存在种族差异。 Sm抗原是剪接复合物的一部分，并催化核前体mRNA的剪接。每个剪接体snRNP包含snRNAs (U1, U2, U4/U6和U5)和一个独特的连接蛋白组，以及一个由7个不同的Sm组成的共享蛋白(SmB/SmB', SmD1, SmD2, SmD3, SmE, SmF和SmG)，分子量分别是9到29,5kDa之间。SmB和SmD多肽是最常见的抗Sm特异性自身免疫应答标靶，其中SmD被看作是主要的SLE特 异性的Sm抗原。 除了重组SmD蛋白（在精氨酸上SmD1和SmD3对称二甲基化）以外，Diarect现在还提供牛源的Sm抗原（非重组）。以上小包装产品现已上市，欢迎您来电查询！ 
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Lyme disease is a multisystemic infectious disease caused by Borrelia species. In the United States Borrelia burgdorferi is the main cause of Lyme disease, in Europe the most dominant species are Borrelia afzelii and Borrelia garinii. Another, even though relatively rare species is Borrelia spielmanii. Lyme disease is the most common tick-borne disease in the Northern Hemisphere. Borrelia is transmitted by the bite of infected ticks from the genus Ixodes. The various clinical manifestations in early disease stage include flu-like symptoms and a characteristic circular skin rash called erythema migrans. Left untreated, the disease is characterized by chronic infection of the joints, heart, and central nervous system. Delayed or inadequate treatment can lead to the serious late manifestations, which can be disabling and difficult to treat. DIARECT now offers a variety of recombinant Borrelia sp. antigens: 
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原发性胆汁性肝硬化(Primary Biliary Cirrhosis; PBC)是一种进行性、慢性胆汁淤积性肝脏疾病，多见于中年女性，并无种族差异。该病病程缓慢，可持续数十年，是一种典型的自身免疫性疾病。PBC在组织 学上表现为肝内小胆管损伤，肝纤维化，最终导致肝硬化。 抗线粒体抗体(anti-mitochondrial antibodies; AMA)已成为PBC临床诊断的重要血清学指标，阳性率高达90%以上。但总有大约10%的PBC患者AMA呈阴性。抗gp210和sp100抗体可作为 有效的生物诊断标志，尤其对AMA阴性的PBC患者来说(Hu, CJ. et al.)。 间接免疫荧光图谱显示gp210和Nup62属于核膜型，Sp100属于多点分布型。gp210是一种分子量为210kDa的跨膜糖蛋白，与核膜一起参与 核孔复合体的粘附，除此之外，它还在真核细胞的核孔复合体转运调节功能中扮演着重要角色。Sp100是一种具有转录调节功能的核蛋白，分子量为 54kDa。与间接免疫荧光法检测多核点抗核抗体相比，肝病患者抗Sp100抗体的血清学检测表现了更强的敏感性，针对PBC的特异性更好。 除了抗gp210的反应外，Wesierska-Gadek, J.等描述了在PBC患者血清中另外一个反应强烈的60kDa蛋白－核孔蛋白p62(Nup62)，顾名思义它是核孔复合物(nuclear pore complex; NPC) 的组成部分，调节具有核定位信号的蛋白进入细胞核，间接免疫荧光图谱显示Nup62也是核膜型。在几位M2阴性的PBC患者血清中，间接免疫荧光图谱展示 了Nup62呈阳性。 许多研究证明抗核抗体(ANA)也是PBC的诊断标志，例如：CENP, Ro/SS-A等。检测其它自身抗体可以对自身免疫性肝病的鉴别，合并自身免疫性疾病的确认有所帮助。Diarect公司提供以上所有与PBC诊断相关的 重组人源抗原。 欢迎您来电查询。 Hu, CJ., Deng, CW., Zhang, W. et al. (2011) Prevalence of Autoimmune Liver Disease Related Autoantibodies in Chinese Patients with Primary Biliary Cirrhosis, Dig Dis Sci56, 3357-63 Wesierska-Gadek, J., Klima, A., Komina, O. et al. (2007) Characterization of autoantibodies against components of the nuclear pore complexes, Ann NY Acad Sc 1109, 519-30 
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We are pleased to introduce BioFX® TMB Enhanced One Component HRP Membrane Substrate, the newest member of SurModics IVD’s BioFX family of quality immunodiagnostic substrates: Features of BioFX® TMB Enhanced HRP Membrane Substrate (Product Code ESPM)
 Free of charge evaluation samples available! Please inquire!
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MEDICA Date: November 16 - 19, 2011 Location: Duesseldorf, Germany Booth: Hall 1 - 1/E17 ACA Autoimmunity Congress Asia Date: November 17 - 19, 2011 Location: Singapore, Republic of Singapore
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 SurModics IVD
9924 West 74th Street
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 Beijing Biobridge Bio-technology Inc. Room 221, Fanghezhengyuan B Building Guanghua Road 16 Tongzhou Industry Development District Beijing 101113 P.R. China Phone: +86 10 61507875 Fax: +86 10 61507837 808 Email: order@bjbiobridge.com.cn www.bjbiobridge.com  Shanghai BioSun Sci&Tech Co., Ltd. Room E2, 6F, Bldg. No.1 825 Zhaojiabang Road Shanghai 200032 P.R. China Phone: +86 21 54253791 Fax: +86 21 64280007 Email: biosun@biosun.cn www.biosun.cn
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If you would like to receive more detailed information on DIARECT products, please follow this link to our contact and order form. |
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