Alanyl-tRNA Synthetase (PL-12)

Cat. No.	Available in
15700	0.1 mg
15701	1 mg

Data Sheet

Specification Sheet

MSDS

Alanyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 108 kDa protein is an autoantigen recognized by PL-12 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that epitope spreading occurs in the autoimmune PL-12 response such that even antibodies to an isolated alanyl-tRNA molecule can develop.

Alanyl-tRNA synthetase (PL-12) from DIARECT is expressed in the baculovirus expression system.

Additional antigenic targets of antibodies from the so-called anti-synthetase complex (PM/DM with autoantibodies against only a single aminoacyl-tRNA synthetase) are threonyl-tRNA synthetase (PL-7) and histidyl-tRNA synthetase (Jo-1), respectively. In the subgroup of non-anti-Jo-1 cases PL-7 and PL-12 together have a prevalence of about 25%.