Centromere Protein A (CENP-A)

Cat. No.Available inproduct_image_40
169000.1 mg
169011 mg
 

Specification Sheet
MSDS

Diseases:
Scleroderma

Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENP-A to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies.

CENP-A is another important centromeric autoantigen in addition to CENP-B: it has a molecular weight of approx. 20 kDa and is incorporated into centromeric chromatin due to its histone-like properties. CENP-A antibodies are an important marker for correct diagnosis of scleroderma/CREST syndrome in CENP-B-autoantibody negative patients.

CENP-A antigen from DIARECT is produced in the baculovirus / insect cell expression system.