Centromere Protein B (CENP-B)

Cat. No.	Available in
12500	0.1 mg
12501	1.0 mg

Specification Sheet

MSDS

Centromere proteins are a group of proteins which form and/or mediate the function of centromeres, the central structures of chromosomes to which spindle fibers/microtubuli attach and pull the chromosomes apart in cell division. Currently, 9 centromere proteins are known and designated CENP-A to CENP-I. Most of the centromere proteins are targets of autoantibodies, the anti-centromere antibodies.

CENP-B is the most important of the centromeric autoantigens: it has a molecular weight of approx. 66 kDa and plays an important role in the formation of the centromeric chromatin. CENP-B antibodies are present in the sera of up to 80% of patients with CREST syndrome.

CENP-B antigen from DIARECT is produced in the baculovirus / insect cell expression system.