dsDNA (plasmid)DNA Topoisomerase I (Scl-70; full length)DNA Topoisomerase I (Scl-70; truncated)Centromere Protein B (CENP-B)Centromere Protein A (CENP-A)Ro/SS-A (60 kDa; recombinant)Ro/SS-A (60 kDa; non-recomb.; bovine)Ro/SS-A (52 kDa)La/SS-BHistidyl-tRNA Synthetase (Jo-1)Threonyl-tRNA Synthetase (PL-7)Alanyl-tRNA Synthetase (PL-12)Mi-2SRP54U1-snRNP 68 Protein (68 kDa)U1-snRNP A ProteinU1-snRNP C ProteinU-snRNP Protein B/B´Proliferating Cell Nuclear Antigen (PCNA)PM/Scl100Ku (p70/p80)Ribosomal Phosphoprotein P0
Formiminotransferase Cyclodeaminase (LC1)
| Cat. No. | Available in |  |
| 13700 | 0.1 mg | |
| 13701 | 1 mg | |
Specification SheetMSDSDiseases:
Autoimmune Hepatitis Type II
Formiminotransferase cyclodeaminase, a bifunctional enzyme of tetrahydrofolate synthesis, is the target antigen of anti-LC1 (liver cytosol antigen type 1) autoantibodies. Presence of LC1 autoantibodies is a marker for type 2 autoimmune hepatitis (for which anti-LKM 1/cytochrome P450 2D6 autoantibodies are a further marker).
Serum LC1 autoantibody concentrations appear to fluctuate in parallel with aminotransferase levels, a particularly intriguing observation that suggests a possible role of LC1 autoreactivity in the pathogenic mechanism leading to hepatocyte injury.
Full-length formiminotransferase cyclodeaminase from DIARECT is produced in the baculovirus expression system.