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Crohn's disease (CD) is one of the two most frequently occurring inflammatory bowel diseases (IBD) in Caucasians. Mucosal inflammation in CD appears to occur when dysregulation of the immune system leads to an imbalance between tolerance to commensal microbiota or food-derived antigens and immunity to pathogens. It has been shown that autoimmune mechanisms play a role in the development of CD, and exocrine pancreas autoantibodies (PAB) are disease-specific in CD patients. Recently, it was demonstrated that glycoprotein 2 (GP2) is the major autoantigenic target recognized by CD-specific PAB. In addition to IgG and IgM PAB isotypes, IgA pancreatic autoantibodies have also been detected in CD patients.
GP2 is a highly glycosylated 78 kDa protein with N-linked carbohydrates. It accounts for up to 40 percent of all zymogen granule (ZG) membrane proteins in pancreatic acinar cells and is linked to the ZG membrane via a glycosyl phosphoinositol (GPI) anchor.
GP2 antigen from DIARECT is produced in the baculovirus / insect cell expression system.