Sm (non recombinant; bovine)

Cat. No.	Available in
17500	0.1 mg
17501	1.0 mg

Specification Sheet

MSDS

Anti-Sm antibodies are highly specific for SLE and are therefore recorded in the classification criteria of the American College of Rheumatology. Anti-Sm antibodies are found in 5 - 30% of patients with SLE, the frequency varying on the detection system and the selection criteria for study cohorts. Also, a racial difference in the incidence of anti-Sm antibodies has been shown. 

The Sm antigen is part of the spliceosomal complex catalyzing the splicing of nuclear pre-mRNA. Each spliceosome snRNP consists of snRNAs (U1, U2, U4/U6, and U5) bound to a unique set of proteins as well as a shared set of seven different Sm proteins with molecular weights between 9 and 29.5 kDa (typically SmB/SmB', SmD1, SmD2, SmD3, SmE, SmF, SmG). Most frequently the SmB and SmD polypeptides are targets of the anti-Sm specific autoimmune response, of which SmD is regarded the most SLE-specific Sm antigen. 

Sm (non recombinant; bovine) from DIARECT is purified from bovine tissue.