Threonyl-tRNA Synthetase (PL-7)

Cat. No.	Available in
15600	0.1 mg
15601	1 mg

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Threonyl-tRNA synthetase is a member of the aminoacyl-tRNA synthetase family, key enzymes of protein biosynthesis which charge tRNA molecules with the respective amino acids. This 83 kDa protein is an autoantigen recognized by PL-7 antibodies which occur in a subset of patients with polymyositis and dermatomyositis. Preliminary data suggest that PL-7 antibodies (similar to Jo-1 antibodies) indicate an increased risk for lung involvement, but this needs to be confirmed for a larger number of cases.

Threonyl-tRNA synthetase (PL-7) from DIARECT is expressed in the baculovirus expression system.

Additional antigenic targets of antibodies from the so-called anti-synthetase-complex (PM/DM with autoantibodies against only a single aminoacyl-tRNA synthetase) are alanyl-tRNA synthetase (PL-12) and histidyl-tRNA synthetase (Jo-1), respectively. In the subgroup of non-anti-Jo-1 cases PL-7 and PL-12 together have a prevalence of about 25% .