DIARECT
 

DIARECT Newsletter

Summary

Dear Madam or Sir,

This year’s MEDICA will be held from November 12 – 15 in Düsseldorf, Germany. As in the previous years, DIARECT will be present with its own booth. As a valued customer we would like to invite you to stop by our booth E19 in hall 1 to find out more about our extended range of products.
In case you wish to schedule an appointment to meet with a member of DIARECT’s team at MEDICA 2014 or to receive more information about other topics of interest, please feel free to contact us at:

Email    info@diarect.com
Tel.     + 49 761 47979-0

Pleasant reading!

DIARECT AG

Website Relaunch

DIARECT is proud to introduce its new website, which has been completely redesigned for an improved product overview, to include the latest product information, and to provide a more user-friendly access from both desktop computers and mobile devices.
In addition to categorizing antigens according to typically reported diseases, the new website contains an antigen overview taking into consideration that an antigen might have synonyms. 

Further, the overview of SurModics protein stabilizers and colorimetric substrates as well as of Lumigen’s chemiluminescent substrates, all distributed by DIARECT, has been updated to facilitate and expedite the finding of your desired product.

Important note to DIARECT’s antigen customers: with the website’s relaunch both the Antigen Specifications and Material Safety Data Sheets have been reviewed and updated according to Regulation (EC) No 1907/2006 (REACH). 
DIARECT hopes the new website will support you better to find out about products, related information, and upcoming events. To access the new website, follow this link.

In case you have a question regarding the new website or the update of the product information material, please feel free to contact us.

New Protein Free AP Conjugate Stabilizer

SurModics IVD NEW StabilZyme® Protein-Free AP Stabilizer is optimized to prevent the loss of Alkaline Phosphatase (AP) activity while maintaining the conformational structure and binding efficacy of the conjugated antibody.

  • Designed for AP conjugated proteins in solution
  • Stabilizes without protein, delivering dependable results
  • Eliminates interference and cross-reactivity
  • Performs across all species of antibodies, even at low concentrations  

                           

Evaluation samples now available!

For additional information please feel free to contact us at:
Tel: +49 761 47979-0
Email: orders@diarect.com

Product Highlight: Borrelia spp. Antigens

Lyme disease is caused by Gram-negative bacteria of the Borrelia burgdorferi sensu lato complex, which has been reported to comprise at least 18 different Borrelia species. While in the United States, B. burgdorferi sensu stricto is considered to be the predominant causative agent of Lyme disease, in Europe several members of the B. burgdorferi sensu lato complex have been identified the be pathogenic to humans: besides B. burgdorferi sensu stricto, this include B. afzelii, B.garinii, B. bavariensis, and B. spielmanii.

DIARECT offers a vast range of recombinant borrelial antigens of B. burgdorferi sensu stricto, B.garinii, B. afzelii, and the less common B. spielmanii. Additional recombinant antigens will be introduced shortly.

Figure: Immunodot analyses of recombinant Borrelia spp. antigens using serum from a blood donor (BD) and sera positive for anti-borrelial antibodies (1-7) as in-house quality control. Abbreviations: Ba – Borrelia afzelii; Bb – B. burgdorferi; Bg – B. garinii; Bs – B. spielmanii.

For additional information please feel free to contact us at:

Tel: +49 761 47979-0
Email: orders@diarect.com

Product Highlight: DNA Topoisomerase I (Scl-70)

DNA Topoisomerase I is a key enzyme in the regulation of DNA supercoiling and the antigen of so-called Scl-70 autoantibodies. In human tissues, DNA Topoisomerase I is synthesized as a 100 kDa precursor, which becomes proteolytically processed to yield the mature 70 kDa enzyme. The latter represents the major antigen of Scl-70 autoantibodies.
DIARECT produces both a full length (Scl-70; full length) and a truncated DNA-Topoisomerase (Scl-70; truncated) resembling the processed form in the baculovirus/insect cell expression system.
To complement the recombinant Scl-70 proteins, DIARECT also offers native DNA Topoisomerase I purified from bovine tissues according to the same quality guidelines applied for recombinant antigens to ensure lot-to-lot consistency.

 

Figure 1: Immunodot analyses of increasing amounts of different lots of Scl-70 truncated (Scl-70; tr.) using sera from blood donors (BD) and patients with presumed systemic sclerosis.

Figure 2: Immunodot analyses of sera from blood donors (BD) and patients with presumed systemic sclerosis. Recombinant full length Scl-70 (Scl-70; f.l.) and truncated Scl-70 (Scl-70; tr.) were analyzed and compared to three different lots of nonrecombinant, native Scl-70 purified from bovine sources (Scl-70; bovine).

For additional information please feel free to contact us at:
Tel: +49 761 47979-0
Email: orders@diarect.com

Distributors in the USA and Canada

To facilitate the purchase of DIARECT’s products throughout the world, DIARECT concluded distribution agreements with select companies.

If you are located in the USA or Canada, DIARECT’s products are exclusively distributed by:

SurModics, Inc.
9924 West 74th Street
Eden Prairie, MN 55344
USA
Tel +1 952 500 7200
Toll-free +1 800 755 7793
Fax +1 952 500 7201
orders@surmodics.com
www.surmodicsivd.com

Distributors in China

To facilitate the purchase of DIARECT’s products throughout the world, DIARECT concluded distribution agreements with select companies.

If you are located in China, DIARECT’s products are distributed by:

Beijing Biobridge Bio-technology Inc.
Room 221, Fanghezhengyuan B Building
Guanghua Road 16
Tongzhou Industry Development District
Beijing 101113
P.R. China
Tel +86 10 61507837
Fax +86 10 61507837 808
biobridge@bjbiobridge.com
www.bjbiobridge.com

Shanghai BioSun Sci&Tech Co., Ltd.
Room K, 5F, Bldg. No.1
825 Zhaojiabang Road
Shanghai 200032
P.R. China
Tel +86 21 54253791
Fax +86 21 64280007
biosun@biosun.cn
www.biosun.cn

Feedback

If you would like to receive more detailed information on DIARECT products, please follow this link to our contact and order form.

Contact Details

  • Address: Bötzinger Straße 29 B, 79111 Freiburg, Germany

  • Phone: +49 761 479 79-0

  • Fax: +49 761 479 79-29

  • Email: info@diarect.com

DIARECT AG is a DIN EN ISO 9001 and 13485 certified company.
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