DIARECT
 

DIARECT Newsletter

Summary

Dear Madam or Sir,

More than 700 companies are expected to exhibit at AACC's 2015 Annual Meeting & Clinical Lab Expo, which will take place from July 26 - 30 in Atlanta, Georgia. As in the previous years, DIARECT will be attending this worldwide leading event for laboratory medicine and would like to invite all attendees to step by its booth #2259.

In case you wish to meet personally with a member of the DIARECT team at this event or to receive more information about other topics of interest, please feel welcome to contact us at:

Email   info@diarect.com
Tel.     +49 761 47979-0

Pleasant reading!

DIARECT AG

Product Launch: Yersinia enterocolitica antigens

Pathogenic Yersinia enterocolitica strains of the serogroups O:3, O:8, and O:9 are the causative agent of yersiniosis, an important gastrointestinal infection in humans. Upon acute infection, these Gram-negative bacteria are capable of spreading from the intestinal tract to other organs, which can lead to the induction of sequelae like reactive arthritis.

To establish infection, pathogenic Y. enterocolitica strains use a plasmid-encoded type III secretion system (T3SS) to inject effector proteins into host cells. In the T3SS, Yersinia outer protein (Yop) B, YopD, and low calcium response V antigen (LcrV) are believed to form a pore in the host cell plasma membrane. During this secretion process, YopN contributes to the timely injection of effector proteins like YopM and YopH into the host cell cytosol. While YopM has been identified to activate ribosomal S6 kinase, YopH acts as a protein tyrosine phosphatase that interferes with the host‘s cellular signaling cascades.

DIARECT's newest product line includes the following Yersinia enterocolitica antigens:

For questions or additional information please feel free to contact us at:
Tel: +49 761 47979-0
Email: orders@diarect.com

Update on DIARECT’s Borrelia spp. antigens

Lyme disease, the most common tick-borne disease in the Northern Hemisphere, is caused by Borrelia species of the B. burgdorferi sensu lato complex that comprises several genospecies. While in Europe the pathogenic genospecies B. afzelii, B. garinii, B. spielmanii, and B. burgdorferi sensu stricto are present, the latter predominates in the United States. A wide range of recombinant Borrelia spp. antigens from these pathogenic genospecies are available from DIARECT. Once again, DIARECT expands this portfolio by adding recombinant B. garinii and recombinant B. afzelii proteins.

Hard body ticks of the genus Ixodes represent the vector of the B. burgdorferi sensu lato complex. However, the relapsing fever group of Borrelia species was thought to be transmitted predominantly by soft body (argasid) ticks of the genus Ornithodoros. The identification of a new Borrelia species of the relapse fever group, B. miyamotoi, in Ixodes ticks in Japan and subsequently in Europe and the Unites States led to the reevaluation of this classification and of B. miyamotoi as a possible infective agent in patients originally diagnosed with Lyme disease.
For the first time, DIARECT offers a recombinant protein from a relapsing fever group Borrelia species: Borrelia miyamotoi GlpQ.

The following Borrelia spp. products are available from DIARECT - expressed and purified in either E. coli or the baculovirus/insect cell expression system:

For questions or additional information please feel free to contact us at:
Tel: +49 761 47979-0
Email: orders@diarect.com

Distributor in North America and Canada

To facilitate the purchase of DIARECT’s products throughout the world, DIARECT concluded distribution agreements with select companies.

If you are located in North America or Canada, DIARECT’s products are exclusively distributed by:

SurModics IVD, Inc.
9924 West 74th Street
Eden Prairie, MN 55344
USA
Tel +1 952 500 7200
Toll-free +1 800 755 7793
Fax +1 952 500 7201
orders@surmodics.com
www.surmodicsivd.com

Distributors in China

To facilitate the purchase of DIARECT’s products throughout the world, DIARECT concluded distribution agreements with select companies.

If you are located in China, DIARECT’s products are distributed by:

Beijing Biobridge Bio-technology Inc.
Room 221, Fanghezhengyuan B Building
Guanghua Road 16
Tongzhou Industry Development District
Beijing 101113
P.R. China
Tel +86 10 61507837
Fax +86 10 61507837 808
biobridge@bjbiobridge.com
www.bjbiobridge.com

Shanghai BioSun Sci&Tech Co., Ltd.
Room K, 5F, Bldg. No.1
825 Zhaojiabang Road
Shanghai 200032
P.R. China
Tel +86 21 54253791
Fax +86 21 64280007
biosun@biosun.cn
www.biosun.cn

Feedback

If you would like to receive more detailed information on DIARECT products, please follow this link to our contact and order form.

Contact Details

  • Address: Bötzinger Straße 29 B, 79111 Freiburg, Germany

  • Phone: +49 761 479 79-0

  • Fax: +49 761 479 79-29

  • Email: info@diarect.com

DIARECT AG is a DIN EN ISO 9001 and 13485 certified company.
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