Autoantigens / Monoclonal Antibodies

* Antigens associated with the following autoimmune diseases*

Systemic Autoimmune Rheumatic Diseases (SARD)

Product Code Quantity Product Name Downloads Data Sheet
30300
30301		 0.1 mg
1.0 mg

DFS70

DFS70 is identical with lens epithelium-derived growth factor/transcription coactivator p75 (LEDGF/p75), a transcription factor attached to chromatin throughout the cell cycle. LEDGF/p75 has been reported to be involved in the cellular stress response as well as the integration of lentiviruses into host chromosomes.		 INFO    
   

Mixed Connective Tissue Disease

Product Code Quantity Product Name Downloads Data Sheet
13000
13001		 0.1 mg
1.0 mg

U1-snRNP 68/70 kDa

Small nucleoprotein particles (snRNPs), comprising non-coding small nuclear RNAs and proteins, are involved in the splicing of eukaryotic mRNA. U1-snRNPs contain three unique proteins with U1-snRNP 68/70 kDa being found as two variants of different size due to alternative splicing.		 INFO
13100
13101		 0.1 mg
1.0 mg

U1-snRNP A

Small nucleoprotein particles (snRNPs), comprising non-coding small nuclear RNAs and proteins, are involved in the splicing of eukaryotic mRNA. U1-snRNPs contain three unique proteins with U1-snRNP 68/70 kDa being found as two variants of different size due to alternative splicing.		 INFO
13200
13201		 0.1 mg
1.0 mg

U1-snRNP C

Small nucleoprotein particles (snRNPs), comprising non-coding small nuclear RNAs and proteins, are involved in the splicing of eukaryotic mRNA. U1-snRNPs contain three unique proteins representing the so-called RNP-specific antigens: U1-snRNP 68/70 kDa, U1-snRNP A, and U1 snRNP C.		 INFO    
13300
13301		 0.1 mg
1.0 mg

U-snRNP B/B'

In eukaryotes, seven Sm proteins bind to U-snRNAs to form U-snRNP complexes (U-snRNPs), which are involved in the splicing of pre-mRNA. Due to alternative mRNA splicing, two isoforms of Sm protein B (named U-snRNP B and U-snRNP B’) are found that differ in size and their C-terminal end.		 INFO    

Systemic Lupus Erythematosus

Product Code Quantity Product Name Downloads Data Sheet
17500
17501		 0.1 mg
1.0 mg

Sm (non recombinant; bovine)

U-small nuclear riboprotein complexes (U-snRNPs), a pivotal component of spliceosomes, are formed between small non-coding nuclear RNAs and a protein moiety. Seven different Sm proteins aggregate into a heteroheptameric protein core, which is conserved between the different U-snRNP subclasses.		 INFO    
11600
11601		 0.1 mg
1.0 mg

RNP/Sm (non recombinant; bovine)

U-small nuclear riboprotein complexes (U-snRNPs), a pivotal component of spliceosomes, are formed between small non-coding nuclear RNAs and a protein moiety. While the seven Sm proteins are conserved, the proteins called RNP antigens are unique for each U-snRNP subclass.		 INFO    
11700
11701		 0.1 mg
1.0 mg

SmD

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD comprises equal masses of SmD1, SmD2, and SmD3. In addition, both SmD1 and SmD3 contain symmetrically dimethylated arginine residues, which represent a major epitope.		 INFO    
11800
11801		 0.1 mg
1.0 mg

SmD1

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. Like native SmD1, DIARECT’s recombinant SmD1 contains symmetrically dimethylated arginine residues.		 INFO    
11900
11901		 0.1 mg
1.0 mg

SmD2

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD2 completes the list of SmD proteins offered by DIARECT.		 INFO    
12000
12001		 0.1 mg
1.0 mg

SmD3

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. Like native SmD3, DIARECT’s recombinant SmD3 contains symmetrically dimethylated arginine residues.		 INFO    
31000
31001		 0.1 mg
1.0 mg

Nucleosome (non recombinant; bovine)

Nucleosome cores are essential for DNA packaging in eukaryotes. Each core consists of an octamer including two copies of each histone 2A, 2B, 3 and 4 around which an approx. 140 bp section of DNA is wound twice. DIARECT provides native nucleosome antigens of bovine origin.		 INFO    
31100
31101		 0.1 mg
1.0 mg

Histone (non recombinant; bovine)

Dynamics of chromatin structure depend on posttranslational modification of histones and appearance of various histone variants. Histone H3 and H4 can be covalently modified (e.g. methylation, acetylation) at several residues. These and H2A/H2B-modifications constitute the so called histone code.		 INFO    
12300
12301		 0.1 mg
1.0 mg

dsDNA (plasmid)

Diarect’s double stranded DNA (dsDNA) is a circular plasmid that is propagated in and purified from Echerichia coli to eliminate potential contaminations with nuclear proteins.		 INFO    
14100
14101		 0.1 mg
1.0 mg

Ribosomal Phosphoprotein P0

Eukaryotic ribosomes are composed of a 40S and a 60S subunit. In the larger subunit, three acidic and phosphorylated proteins, the so-called ribosomal phosphoproteins P0-P2, have been identified. P0 is the largest phosphoprotein with a molecular weight of 38 kDa.		 INFO    
14200
14201		 0.1 mg
1.0 mg

Ribosomal Phosphoprotein P1

The eukaryotic 60S ribosomal subunit comprises ribosomal RNA and mostly basic proteins. In addition, three acidic and phosphorylated proteins (P0, P1, P2) have been identified. With a molecular weight of 19 kDa, P1 is the second largest ribosomal phosphoprotein.		 INFO    
14300
14301		 0.1 mg
1.0 mg

Ribosomal Phosphoprotein P2

The eukaryotic 60S ribosomal subunit comprises ribosomal RNA and mostly basic proteins. In addition, three acidic and phosphorylated proteins (P0, P1, P2) have been identified. With a molecular weight of 17 kDa, P2 is the smallest ribosomal phosphoprotein.		 INFO    
15400
15401		 0.1 mg
1.0 mg

Proliferating Cell Nuclear Antigen (PCNA)

Proliferating cell nuclear antigen (PCNA; syn. Cyclin) is a co-factor of DNA polymerase delta, forms homotrimers around double stranded DNA, and is involved in DNA replication and repair. Since its expression rate correlates with the rate of DNA replication, PCNA is a proliferation marker in basic research.		 INFO
36600

 0.1 mg

PCNA humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides human chimeric PCNA IgG antibody ideally paired with our PCNA antigen.		 INFO    
17300
17301		 0.1 mg
1.0 mg

Ku (p70/p80)

Eukaryotic Ku is a heterodimeric DNA binding protein formed by the p70 and p80 subunits that were named according to their respective molecular weight. Ku is a key factor of the non-homologous end joining (NHEJ) DNA repair pathway by directly binding to DNA ends created at DNA double strand breaks.		 INFO
19700
19701		 0.1 mg
1.0 mg

Nucleolin

The phosphoprotein nucleolin primarily localizes to the nucleolus where it is involved in the regulation of rRNA gene transcription and ribosome assembly. In addition, nucleolin is also implicated in mRNA translation and turnover in the cytoplasm highlighting its multiple cellular functions.		 IMFO
   

Sjøgrens Syndrome

Product Code Quantity Product Name Downloads Data Sheet
17400
17401		 0.1 mg
1.0 mg

Ro/SS-A (60 kDa; recombinant)

Ro/SS-A is a ribonucleoprotein particle (RNP) that is suggested to be involved in RNA quality control and the cellular stress response to UV irradiation. It is composed of uridine-rich cytoplasmic (hY) RNAs and at least four different proteins including Ro/SS-A (60 kDa).		 INFO    
20300
20301		 0.05 mg
  0.5 mg

Ro/SS-A (60 kDa; rec.) biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated Ro/SS-A (60 kDa; rec.) represents a further development of the established antigen.		 INFO    
15500
15501		 0.1 mg
1.0 mg

Ro/SS-A (60 kDa; non recombinant; bovine)

Ro/SS-A is a ribonucleoprotein particle (RNP) that is suggested to be involved in RNA quality control and the cellular stress response to UV irradiation. It is composed of uridine-rich cytoplasmic (hY) RNAs and at least four different proteins including Ro/SS-A (60 kDa).		 INFO    
20400
20401		 0.05 mg
  0.5 mg

Ro/SS-A (60 kDa; non rec.; bov.) biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated Ro/SS-A (60 kDa; non rec.; bov.) represents a further development of the established antigen.		 INFO    
12700
12701		 0.1 mg
1.0 mg

Ro/SS-A (52 kDa)

Ro/SS-A is a ribonucleoprotein particle (RNP) that is suggested to be involved in RNA quality control and the cellular stress response to UV irradiation. It is composed of uridine-rich cytoplasmic (hY) RNAs and at least four different proteins including Ro/SS-A (52 kDa), which is also known as TRIM21.		 INFO    
20500
20501		 0.05 mg
  0.5 mg

Ro/SS-A (52 kDa) biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated Ro/SS-A (52 kDa) represents a further development of the established antigen.		 INFO    
12800
12801		 0.1 mg
1.0 mg

La/SS-B

La/SS-B is a nuclear phosphoprotein that binds to transcripts of RNA polymerase III. These transcripts include the ribosomal 5S RNA, tRNAs, as well as the small nuclear RNAs U1 and U6, which are part of the spliceosome.		 INFO    
20600
20601		 0.05 mg
  0.5 mg

La/SS-B biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated La/SS-B represents a further development of the established antigen.		 INFO    
 

Systemic Sclerosis / CREST Syndrome

Product Code Quantity Product Name Downloads Data Sheet
12500
12501		 0.1 mg
1.0 mg

Centromere Protein B (CENP-B)

The centromere is a defined DNA region of a chromosome where the sister chromatids are connected and the attachment site of the kinetochore. Centromere protein B (CENP-B) binds to this DNA region and is involved in the assembly of the kinetochore.		 INFO    
16900
16901		 0.1 mg
1.0 mg

Centromere Protein A (CENP-A)

The centromere is a defined DNA region of a chromosome where the sister chromatids are connected and the attachment site of the kinetochore. Centromere Protein A (CENP-A) is a histone H3 variant defining the location and function of the centromeres.		 INFO    
12400
12401		 0.1 mg
1.0 mg

DNA Topoisomerase I (Scl-70; full length)

DNA Topoisomerase I is an enzyme that adjusts the supercoiling stage of DNA to resolve torsional stress occurring during DNA transcription and replication. Proteolytical processing matures the 100 kDa precursor into the 70 kDa form. Scl-70 full length corresponds to the 100 kDa precursor.		 INFO  
14500
14501		 0.1 mg
1.0 mg

DNA Topoisomerase I (Scl-70; truncated)

DNA Topoisomerase I is an enzyme that adjusts the supercoiling stage of DNA to resolve torsional stress occurring during DNA transcription and replication. Proteolytical processing matures the 100 kDa precursor into the 70 kDa form. Scl-70 truncated corresponds to the mature 70 kDa form.
 INFO    
11500
11501		 0.1 mg
1.0 mg

DNA Topoisomerase I (Scl-70; non recombinant; bovine)

DNA Topoisomerase I is an enzyme that adjusts the supercoiling stage of DNA to resolve torsional stress occurring during DNA transcription and replication. Proteolytical processing matures the 100 kDa precursor into the 70 kDa form.		 INFO    
16000
16001		 0.1 mg
1.0 mg

PM/Scl 100

The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 100 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.
 INFO    
17000
17001		 0.1 mg
1.0 mg

PM/Scl 75

The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 75 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.		 INFO    
   

Polymyositis / Dermatomyositis

Product Code Quantity Product Name Downloads Data Sheet
12900
12901		 0.1 mg
1.0 mg

Histidyl-tRNA Synthetase (Jo-1)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Histidyl-tRNA synthetase (Jo-1) is specific for the amino acid histidine.		 INFO    
15600
15601		 0.1 mg
1.0 mg

Threonyl-tRNA Synthetase (PL-7)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Threonyl-tRNA synthetase (PL-7) is specific for the amino acid threonine.		 INFO    
15700
15701		 0.1 mg
1.0 mg

Alanyl-tRNA Synthetase (PL-12)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Alanyl-tRNA synthetase (PL-12) is specific for the amino acid alanine.		 INFO    
11100
11101		 0.1 mg
1.0 mg

Glycyl-tRNA Synthetase (EJ)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Glycyl-tRNA synthetase (EJ) is specific for the amino acid glycine.		 INFO    
30100
30101		 0.1 mg
1.0 mg

Asparaginyl-tRNA Synthetase (KS)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Asparaginyl-tRNA synthetase (KS) is specific for the amino acid asparagine.		 INFO    
18400
18401		 0.1 mg
1.0 mg

SRP54

The signal recognition particle (SRP) recruits secretory and transmembrane proteins to the endoplasmic reticulum (ER) where co-translational translocation across the ER membrane occurs. SRP54 is the SRP subunit directly binding to the N-terminal signal peptide of these proteins.		 INFO    
36500

 0.1 mg

SRP54 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides human chimeric SRP54 IgG antibody ideally paired with our SRP54 antigen.		 INFO    
16000
16001		 0.1 mg
1.0 mg

PM/Scl 100

The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 100 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.		 INFO    
17000
17001		 0.1 mg
1.0 mg

PM/Scl 75

The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 75 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.		 INFO    
18100
18101		 0.1 mg
1.0 mg

Mi-2

The nucleosome remodeling deacetylase (NuRD) complex exerts histone deacetylase activity and functions in the regulation of gene transcription. Mi-2, a subunit of the NuRD complex, is a DNA-dependent ATPase helicase and appears to be involved in the repair of the basal epidermis.		 INFO    
36700

 0.1 mg

Mi-2 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides human chimeric Mi-2 humAb IgG antibody ideally paired with our Mi-2 antigen.		 INFO    
11000
11001		 0.1 mg
1.0 mg

TIF1 gamma

Transcriptional intermediary factor 1-gamma (TIF1 gamma), originally named p155 and synonymous for p155/140 and TRIM33, is a nuclear protein that functions as a mono-ubiquitin ligase for Smad4, a TGF-β signal transducer, leading to its inactivation. Consequently, the TGF-β signaling pathway, a major pathway for control of cell growth and differentiation, is downregulated.

INFO

    
30000
30001		 0.1 mg
1.0 mg

MDA5

As a part of the innate immune system, the cytoplasmic melanoma differentiation-associated protein 5 (MDA5; syn. CADM 140), a member of the retinoic-acid-inducible gene-I like receptors, has a role in the recognition of viral RNAs. The expression of MDA5 can be induced by type I interferons.		 INFO
   

Autoimmune Thyroid Diseases

Product Code Quantity Product Name Downloads Data Sheet
12100
12101		 0.1 mg
1.0 mg

Thyroid Peroxidase (TPO)

The membrane protein thyroid peroxidase (TPO; syn. MSA) is a key enzyme in the synthesis of thyroid hormones and identical with the so-called “thyroid microsomal antigen”. Recombinant TPO is expressed as a soluble variant comprising the extracellular domain targeted by anti-TPO autoantibodies.		 INFO    
20100
20101		 0.05 mg
  0.5 mg

Thyroid Peroxidase (TPO) biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated TPO represents a further development of the established antigen.		 INFO    
12200
12201		 0.1 mg
1.0 mg

Thyroglobulin (non recombinant)

The dimeric glycoprotein thyroglobulin, synonym for TG, is a pivotal precursor in the synthesis of thyroid hormones and comprises up to 75% of the total protein mass of the thyroid gland. It often co-purifies with thyroid peroxidase in native “thyroid microsomal antigen preparations” and is also a target of autoantibodies.		 INFO    
20200
20201		 0.05 mg
  0.5 mg

Thyroglobulin (non rec.) biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated TG represents a further development of the established antigen.		 INFO    
   

Celiac Disease

Product Code Quantity Product Name Downloads Data Sheet
15200
15201		 0.1 mg
1.0 mg

Tissue Transglutaminase (tTG; expressed in Baculovirus/Sf9)

Tissue transglutaminase (tTG; syn. TGase-2) is an ubiquitously expressed enzyme, which exerts protein deamidation and transamidation activity leading to the creation of neo-epitopes and the cross-linking of proteins, respectively. DIARECT’s tTG has been sequence modified to eliminate this cross-linking activity and to prevent covalent aggregates of tTG with host cell proteins.		 INFO    
14400
14401		 0.1 mg
1.0 mg

Tissue Transglutaminase (tTG; expressed in E.coli)

Tissue transglutaminase (tTG; syn. TGase-2) is an ubiquitously expressed enzyme, which exerts protein deamidation and transamidation activity leading to the creation of neo-epitopes and the cross-linking of proteins, respectively. DIARECT’s tTG has been sequence modified to eliminate this cross-linking activity and to prevent covalent aggregates of tTG with host cell proteins.		 INFO    
19500
19501		 0.1 mg
1.0 mg

Gliadin (recombinant; deamidated)

Gliadin describes a class storage proteins found in wheat grains. Based on its solubility, α-,β-,γ-, and ω-gliadin can be distinguished. Gliadin is a common substrate of transglutminase, which generates neo-epitopes by deamidation of glutamine side chains. The sequence of DIARECT’s Gliadin fragment has been design to contain these neo-epitopes.		 INFO    
   

Autoimmune Hepatitis

Product Code Quantity Product Name Downloads Data Sheet
19800
19801		 0.1 mg
1.0 mg

Cytochrome P450 2D6 (LKM 1 hp)

Cytochrome p450 2D6 is a cytochrome p450 mono-oxygenase that is primarily expressed in the liver and identical with the so-called liver-kidney microsome 1 (LKM1) antigen. This enzyme localizes to the endoplasmic reticulum and is involved in the detoxification of xenobiotic substances.		 INFO  
36400
36401		 0.1 mg
1.0 mg

LKM1 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides human chimeric LKM1 IgG antibody ideally paired with our LKM1 antigen.		 INFO    
13700
13701		 0.1 mg
1.0 mg

Formiminotransferase Cyclodeaminase (LC1)

Human formiminotransferase cyclodeamidase (FTCD) is an approximately 60 kDa, liver specific, bifunctional enzyme, involved in both histidine and folate metabolism. It is identical with the so-called liver cytosol type 1 antigen (LC1), and has been reported to oligomerize in the cytoplasm.		 INFO    
   

Primary Biliary Cirrhosis

Product Code Quantity Product Name Downloads Data Sheet
18000
18001		 0.1 mg
1.0 mg

M2

Mitochondrial 2-oxo acid dehydrogenase multienzyme complexes play a pivotal role in the regulation of the cellular redox state. M2 is the synonym for a cellular antigen comprising the E2-subunits of distinct dehydrogenase complexes, namely PDC-E2, OGDC-E2, and BCOADC-E2.		 INFO    
17700
17701		 0.1 mg
1.0 mg

BCOADC-E2

Branched chain 2-oxo acid dehydrogenase complex (BCOADC) is a mitochondrial multienzyme complex involved in the maintenance of the cellular redox state. BCOADC-E2 is the central E2 component of this complex.		 INFO    
17800
17801		 0.1 mg
1.0 mg

OGDC-E2

2-oxoglutarate dehydrogenase complex (OGDC) is a mitochondrial multienzyme complex involved in the maintenance of the cellular redox state. OGDC-E2 is the central E2 component of this complex.		 INFO    
17900
17901		 0.1 mg
1.0 mg

PDC-E2

The pyruvate dehydrogenase complex (PDC) is a mitochondrial multienzyme complex involved in the maintenance of the cellular redox state. PDC-E2 is the central E2 component of this complex.		 INFO    
18900
18901		 0.1 mg
1.0 mg

Sp100

Sp100 is a 100 kDa nuclear protein, which appears as a speckled pattern in immunofluorescence assays. The function of Sp100 is not well understood, but recent findings suggest a role in the cellular response to viral infections.		 INFO    
19000
19001		 0.1 mg
1.0 mg

gp210

In eukaryotic cells, transport between the cytoplasm and the nucleus occurs via the nuclear pore complex. One component of this complex, the evolutionary conserved gp210, is an integral membrane glycoprotein.		 INFO    
19400
19401		 0.1 mg
1.0 mg

Nup62

The nucleoporin Nup62 represents a major component of the nuclear pore complex that is directly involved in the regulation of molecular trafficking between the nucleus and the cytoplasm. In addition, a role in centrosome homeostasis has been reported.		 INFO    
   

ANCA Associated Diseases

Product Code Quantity Product Name Downloads Data Sheet
18500
18501		 0.1 mg
1.0 mg

Myeloperoxidase (MPO; non recombinant)

Myeloperoxidase (MPO) is a heme containing enzyme of neutrophil granulocytes, which contributes to the destruction of phagocytosed microorganisms by catalyzing the conversion of hydrogen peroxide to hypochlorous acid within the phagosome.		 INFO    
18600
18601		 0.1 mg
1.0 mg

Proteinase 3 (PR3; non recombinant)

Proteinase 3 (PR3) is a serine protease stored in cytoplasmic azurophilic granules of neutrophil granulocytes, where it is involved in the degradation of microorganisms within the phagolysosomes. In addition, PR3 contributes to the destruction of pathogens in the extracellular environment.		 INFO   
19200
19201		 0.1 mg
1.0 mg

BPI (non recombinant)

Bactericidal/permeability-increasing protein (BPI) was originally identified in the azurophilic granules of neutrophil granulocytes as part of the innate immune system. It is an endogenous antibiotic protein that binds lipopolysaccharide (LPS) and kills Gram-negative bacteria.		 INFO  
   

Antiphospholipid Syndrome/ Thromboembolic Syndrome

Product Code Quantity Product Name Downloads Data Sheet
14900
14901		 0.1 mg
1.0 mg

ß2-Glycoprotein 1 (Apolipoprotein H)

The glycosylated plasma protein β2-glycoprotein 1 (β2-GP1), formerly known as Apolipoprotein H (Apo H), has been shown to bind charged phospholipids, especially cardiolipin. Further, an anti-coagulant function of β2-GP1 has been described.		 INFO    
11300
11301		 0.1 mg
1.0 mg

ß2-Glycoprotein 1 (Apo H; non recombinant; human)

Glycosylated plasma protein β2-glycoprotein 1 (β2-GP1), formerly known as Apolipoprotein H (Apo H), has been shown to bind charged phospholipids, especially cardiolipin. Further, an anti-coagulant function of β2-GP1 has been described.		 INFO    
11400
11401		 0.1 mg
1.0 mg

ß2-Glycoprotein 1 (Apo H; non recombinant; bovine)

Glycosylated plasma protein β2-glycoprotein 1 (β2-GP1), formerly known as Apolipoprotein H (Apo H), has been shown to bind charged phospholipids, especially cardiolipin. Further, an anti-coagulant function of β2-GP1 has been described.		 INFO    
   

Anti-GBM Disease

Product Code Quantity Product Name Downloads Data Sheet
16800
16801		 0.1 mg
1.0 mg

Glomerular Basement Membrane (GBM; dissociated)

The glomerulus represents the blood filtering unit of the kidney and contains the glomerular basement membrane (GBM), which lines the capillaries. The GBM comprises type IV collagen heterotrimers formed by the collagen alpha-3(IV) chain. DIARECT offers a recombinant minicollagen variant of this protein.		 INFO    
20700
20701		 0.05 mg
  0.5 mg

GBM biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated GBM represents a further development of the established antigen.		 INFO    
   

Diabetes Mellitus

Product Code Quantity Product Name Downloads Data Sheet
13800
13801		 0.1 mg
1.0 mg

Glutamate Decarboxylase 65 kDa (GAD65)

The 65kDa-enzyme glutamate decarboxylase (GAD65) catalyzes the decarboxylation of glutamate to gamma-aminobutyrate (GABA). In human cells, GAD65 localizes to the vicinity of the Golgi apparatus and vesicles containing GABA.		 INFO    
20800
20801		 0.05 mg
  0.5 mg

GAD65 biotinylated

Binding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated GAD65 represents a further development of the established antigen.		 INFO    
30500
30501		 0.1 mg
1.0 mg

IA-2 (ICA 512)

Insulinoma-associated protein (IA-2), also called islet cell antigen 512 (ICA 512), is a catalytically inactive protein tyrosine phosphatase (PTP)-like protein and a major target of autoimmune response in diabetes mellitus. The long C-terminal intracellular tail, harbors the majority of autoantibody epitopes. IA-2 is expressed within secretory granules in neural, neuroendocrine and pancreatic islet cells.		 INFO    
 

Pernicious Anemia

Product Code Quantity Product Name Downloads Data Sheet
16700
16701		 0.1 mg
1.0 mg

Intrinsic Factor

Cobalamin/vitamin B12 is essential for the formation of blood cells and DNA synthesis, and needs to be taken up with the diet. Intrinsic factor, which is secreted by the stomach, binds to vitamin B12 in the small intestine to allow its endocytosis in the ileum.		 INFO    
   

Crohn’s Disease

Product Code Quantity Product Name Downloads Data Sheet
19600
19601		 0.1 mg
1.0 mg

GP2

Glycoprotein 2 (GP2) is a GPI-anchored protein abundantly produced by the pancreas, but is also expressed on intestinal membranous cells (M-cells), where it serves as a receptor for the phagocytosis of FimH+ Gram-negative bacteria to induce the mucosal immune response. Some results suggest an additional immunosuppressive and anti-inflammatory function of GP2.		 INFO