Autoantigens / Monoclonal Antibodies
* Antigens associated with the following autoimmune diseases*
Systemic Autoimmune Rheumatic Diseases (SARD)
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 30300 30301 | 0.1 mg 1.0 mg | DFS70DFS70 is identical with lens epithelium-derived growth factor/transcription coactivator p75 (LEDGF/p75), a transcription factor attached to chromatin throughout the cell cycle. LEDGF/p75 has been reported to be involved in the cellular stress response as well as the integration of lentiviruses into host chromosomes. | INFO | |||||
Mixed Connective Tissue Disease
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 13000 13001 | 0.1 mg 1.0 mg | U1-snRNP 68/70 kDaSmall nucleoprotein particles (snRNPs), comprising non-coding small nuclear RNAs and proteins, are involved in the splicing of eukaryotic mRNA. U1-snRNPs contain three unique proteins with U1-snRNP 68/70 kDa being found as two variants of different size due to alternative splicing. | INFO | |||||
| 13100 13101 | 0.1 mg 1.0 mg | U1-snRNP ASmall nucleoprotein particles (snRNPs), comprising non-coding small nuclear RNAs and proteins, are involved in the splicing of eukaryotic mRNA. U1-snRNPs contain three unique proteins with U1-snRNP 68/70 kDa being found as two variants of different size due to alternative splicing. | INFO | |||||
| 13200 13201 | 0.1 mg 1.0 mg | U1-snRNP CSmall nucleoprotein particles (snRNPs), comprising non-coding small nuclear RNAs and proteins, are involved in the splicing of eukaryotic mRNA. U1-snRNPs contain three unique proteins representing the so-called RNP-specific antigens: U1-snRNP 68/70 kDa, U1-snRNP A, and U1 snRNP C. | INFO | |||||
| 13300 13301 | 0.1 mg 1.0 mg | U-snRNP B/B'In eukaryotes, seven Sm proteins bind to U-snRNAs to form U-snRNP complexes (U-snRNPs), which are involved in the splicing of pre-mRNA. Due to alternative mRNA splicing, two isoforms of Sm protein B (named U-snRNP B and U-snRNP B’) are found that differ in size and their C-terminal end. | INFO | |||||
Systemic Lupus Erythematosus
| Product Code | Quantity | Product Name | Downloads | Data Sheet | |||||
|---|---|---|---|---|---|---|---|---|---|
| 17500 17501 | 0.1 mg 1.0 mg | Sm (non recombinant; bovine)U-small nuclear riboprotein complexes (U-snRNPs), a pivotal component of spliceosomes, are formed between small non-coding nuclear RNAs and a protein moiety. Seven different Sm proteins aggregate into a heteroheptameric protein core, which is conserved between the different U-snRNP subclasses. | INFO | ||||||
| 11600 11601 | 0.1 mg 1.0 mg | RNP/Sm (non recombinant; bovine)U-small nuclear riboprotein complexes (U-snRNPs), a pivotal component of spliceosomes, are formed between small non-coding nuclear RNAs and a protein moiety. While the seven Sm proteins are conserved, the proteins called RNP antigens are unique for each U-snRNP subclass. | INFO | ||||||
| 11700 11701 | 0.1 mg 1.0 mg | SmDIn eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD comprises equal masses of SmD1, SmD2, and SmD3. In addition, both SmD1 and SmD3 contain symmetrically dimethylated arginine residues, which represent a major epitope. | INFO | ||||||
| 11800 11801 | 0.1 mg 1.0 mg | SmD1In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. Like native SmD1, DIARECT’s recombinant SmD1 contains symmetrically dimethylated arginine residues. | INFO | ||||||
| 11900 11901 | 0.1 mg 1.0 mg | SmD2In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD2 completes the list of SmD proteins offered by DIARECT. | INFO | ||||||
| 12000 12001 | 0.1 mg 1.0 mg | SmD3In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. Like native SmD3, DIARECT’s recombinant SmD3 contains symmetrically dimethylated arginine residues. | INFO | ||||||
| 31000 31001 | 0.1 mg 1.0 mg | Nucleosome (non recombinant; bovine)Nucleosome cores are essential for DNA packaging in eukaryotes. Each core consists of an octamer including two copies of each histone 2A, 2B, 3 and 4 around which an approx. 140 bp section of DNA is wound twice. DIARECT provides native nucleosome antigens of bovine origin. | INFO | ||||||
| 31100 31101 | 0.1 mg 1.0 mg | Histone (non recombinant; bovine)Dynamics of chromatin structure depend on posttranslational modification of histones and appearance of various histone variants. Histone H3 and H4 can be covalently modified (e.g. methylation, acetylation) at several residues. These and H2A/H2B-modifications constitute the so called histone code. | INFO | ||||||
| 12300 12301 | 0.1 mg 1.0 mg | dsDNA (plasmid)Diarect’s double stranded DNA (dsDNA) is a circular plasmid that is propagated in and purified from Echerichia coli to eliminate potential contaminations with nuclear proteins. | INFO | ||||||
| 14100 14101 | 0.1 mg 1.0 mg | Ribosomal Phosphoprotein P0Eukaryotic ribosomes are composed of a 40S and a 60S subunit. In the larger subunit, three acidic and phosphorylated proteins, the so-called ribosomal phosphoproteins P0-P2, have been identified. P0 is the largest phosphoprotein with a molecular weight of 38 kDa. | INFO | ||||||
| 14200 14201 | 0.1 mg 1.0 mg | Ribosomal Phosphoprotein P1The eukaryotic 60S ribosomal subunit comprises ribosomal RNA and mostly basic proteins. In addition, three acidic and phosphorylated proteins (P0, P1, P2) have been identified. With a molecular weight of 19 kDa, P1 is the second largest ribosomal phosphoprotein. | INFO | ||||||
| 14300 14301 | 0.1 mg 1.0 mg | Ribosomal Phosphoprotein P2The eukaryotic 60S ribosomal subunit comprises ribosomal RNA and mostly basic proteins. In addition, three acidic and phosphorylated proteins (P0, P1, P2) have been identified. With a molecular weight of 17 kDa, P2 is the smallest ribosomal phosphoprotein. | INFO | ||||||
| 15400 15401 | 0.1 mg 1.0 mg | Proliferating Cell Nuclear Antigen (PCNA)Proliferating cell nuclear antigen (PCNA; syn. Cyclin) is a co-factor of DNA polymerase delta, forms homotrimers around double stranded DNA, and is involved in DNA replication and repair. Since its expression rate correlates with the rate of DNA replication, PCNA is a proliferation marker in basic research. | INFO | ||||||
| 36600 36601 | 0.1 mg 1.0 mg | PCNA humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PCNA IgG antibody ideally paired with our PCNA antigen. | INFO | ||||||
| 17300 17301 | 0.1 mg 1.0 mg | Ku (p70/p80)Eukaryotic Ku is a heterodimeric DNA binding protein formed by the p70 and p80 subunits that were named according to their respective molecular weight. Ku is a key factor of the non-homologous end joining (NHEJ) DNA repair pathway by directly binding to DNA ends created at DNA double strand breaks. | INFO | ||||||
| 19700 19701 | 0.1 mg 1.0 mg | NucleolinThe phosphoprotein nucleolin primarily localizes to the nucleolus where it is involved in the regulation of rRNA gene transcription and ribosome assembly. In addition, nucleolin is also implicated in mRNA translation and turnover in the cytoplasm highlighting its multiple cellular functions. | IMFO | ||||||
Sjøgrens Syndrome
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 17400 17401 | 0.1 mg 1.0 mg | Ro/SS-A (60 kDa; recombinant)Ro/SS-A is a ribonucleoprotein particle (RNP) that is suggested to be involved in RNA quality control and the cellular stress response to UV irradiation. It is composed of uridine-rich cytoplasmic (hY) RNAs and at least four different proteins including Ro/SS-A (60 kDa). | INFO | |||||
| 20300 20301 | 0.05 mg 0.5 mg | Ro/SS-A (60 kDa; rec.) biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated Ro/SS-A (60 kDa; rec.) represents a further development of the established antigen. | INFO | |||||
| 15500 15501 | 0.1 mg 1.0 mg | Ro/SS-A (60 kDa; non recombinant; bovine)Ro/SS-A is a ribonucleoprotein particle (RNP) that is suggested to be involved in RNA quality control and the cellular stress response to UV irradiation. It is composed of uridine-rich cytoplasmic (hY) RNAs and at least four different proteins including Ro/SS-A (60 kDa). | INFO | |||||
| 20400 20401 | 0.05 mg 0.5 mg | Ro/SS-A (60 kDa; non rec.; bov.) biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated Ro/SS-A (60 kDa; non rec.; bov.) represents a further development of the established antigen. | INFO | |||||
| 12700 12701 | 0.1 mg 1.0 mg | Ro/SS-A (52 kDa)Ro/SS-A is a ribonucleoprotein particle (RNP) that is suggested to be involved in RNA quality control and the cellular stress response to UV irradiation. It is composed of uridine-rich cytoplasmic (hY) RNAs and at least four different proteins including Ro/SS-A (52 kDa), which is also known as TRIM21. | INFO | |||||
| 20500 20501 | 0.05 mg 0.5 mg | Ro/SS-A (52 kDa) biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated Ro/SS-A (52 kDa) represents a further development of the established antigen. | INFO | |||||
| 12800 12801 | 0.1 mg 1.0 mg | La/SS-BLa/SS-B is a nuclear phosphoprotein that binds to transcripts of RNA polymerase III. These transcripts include the ribosomal 5S RNA, tRNAs, as well as the small nuclear RNAs U1 and U6, which are part of the spliceosome. | INFO | |||||
| 20600 20601 | 0.05 mg 0.5 mg | La/SS-B biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated La/SS-B represents a further development of the established antigen. | INFO | |||||
Systemic Sclerosis / CREST Syndrome
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 12500 12501 | 0.1 mg 1.0 mg | Centromere Protein B (CENP-B)The centromere is a defined DNA region of a chromosome where the sister chromatids are connected and the attachment site of the kinetochore. Centromere protein B (CENP-B) binds to this DNA region and is involved in the assembly of the kinetochore. | INFO | |||||
| 16900 16901 | 0.1 mg 1.0 mg | Centromere Protein A (CENP-A)The centromere is a defined DNA region of a chromosome where the sister chromatids are connected and the attachment site of the kinetochore. Centromere Protein A (CENP-A) is a histone H3 variant defining the location and function of the centromeres. | INFO | |||||
| 12400 12401 | 0.1 mg 1.0 mg | DNA Topoisomerase I (Scl-70; full length)DNA Topoisomerase I is an enzyme that adjusts the supercoiling stage of DNA to resolve torsional stress occurring during DNA transcription and replication. Proteolytical processing matures the 100 kDa precursor into the 70 kDa form. Scl-70 full length corresponds to the 100 kDa precursor. | INFO | |||||
| 14500 14501 | 0.1 mg 1.0 mg | DNA Topoisomerase I (Scl-70; truncated)DNA Topoisomerase I is an enzyme that adjusts the supercoiling stage of DNA to resolve torsional stress occurring during DNA transcription and replication. Proteolytical processing matures the 100 kDa precursor into the 70 kDa form. Scl-70 truncated corresponds to the mature 70 kDa form. | INFO | |||||
| 11500 11501 | 0.1 mg 1.0 mg | DNA Topoisomerase I (Scl-70; non recombinant; bovine)DNA Topoisomerase I is an enzyme that adjusts the supercoiling stage of DNA to resolve torsional stress occurring during DNA transcription and replication. Proteolytical processing matures the 100 kDa precursor into the 70 kDa form. | INFO | |||||
| 16000 16001 | 0.1 mg 1.0 mg | PM/Scl 100The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 100 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus. | INFO | |||||
| 17000 17001 | 0.1 mg 1.0 mg | PM/Scl 75The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 75 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus. | INFO | |||||
Polymyositis / Dermatomyositis
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 12900 12901 | 0.1 mg 1.0 mg | Histidyl-tRNA Synthetase (Jo-1)For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Histidyl-tRNA synthetase (Jo-1) is specific for the amino acid histidine. | INFO | |||||
| 15600 15601 | 0.1 mg 1.0 mg | Threonyl-tRNA Synthetase (PL-7)For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Threonyl-tRNA synthetase (PL-7) is specific for the amino acid threonine. | INFO | |||||
| 36800 36801 | 0.1 mg 1.0 mg | PL-7 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PL-7 IgG antibody ideally paired with our PL-7 antigen. | INFO | |||||
| 15700 15701 | 0.1 mg 1.0 mg | Alanyl-tRNA Synthetase (PL-12)For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Alanyl-tRNA synthetase (PL-12) is specific for the amino acid alanine. | INFO | |||||
| 36900 36901 | 0.1 mg 1.0 mg | PL-12 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PL-12 IgG antibody ideally paired with our PL-12 antigen. | INFO | |||||
| 11100 11101 | 0.1 mg 1.0 mg | Glycyl-tRNA Synthetase (EJ)For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Glycyl-tRNA synthetase (EJ) is specific for the amino acid glycine. | INFO | |||||
| 30100 30101 | 0.1 mg 1.0 mg | Asparaginyl-tRNA Synthetase (KS)For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Asparaginyl-tRNA synthetase (KS) is specific for the amino acid asparagine. | INFO | |||||
| 18400 18401 | 0.1 mg 1.0 mg | SRP54The signal recognition particle (SRP) recruits secretory and transmembrane proteins to the endoplasmic reticulum (ER) where co-translational translocation across the ER membrane occurs. SRP54 is the SRP subunit directly binding to the N-terminal signal peptide of these proteins. | INFO | |||||
| 36500 36501 | 0.1 mg 1.0 mg | SRP54 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric SRP54 IgG antibody ideally paired with our SRP54 antigen. | INFO | |||||
| 16000 16001 | 0.1 mg 1.0 mg | PM/Scl 100The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 100 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus. | INFO | |||||
| 17000 17001 | 0.1 mg 1.0 mg | PM/Scl 75The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 75 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus. | INFO | |||||
| 18100 18101 | 0.1 mg 1.0 mg | Mi-2The nucleosome remodeling deacetylase (NuRD) complex exerts histone deacetylase activity and functions in the regulation of gene transcription. Mi-2, a subunit of the NuRD complex, is a DNA-dependent ATPase helicase and appears to be involved in the repair of the basal epidermis. | INFO | |||||
| 36700 36701 | 0.1 mg 1.0 mg | Mi-2 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric Mi-2 antibody ideally paired with our Mi-2 antigen. | INFO | |||||
| 11000 11001 | 0.1 mg 1.0 mg | TIF1 gammaTranscriptional intermediary factor 1-gamma (TIF1 gamma), originally named p155 and synonymous for p155/140 and TRIM33, is a nuclear protein that functions as a mono-ubiquitin ligase for Smad4, a TGF-β signal transducer, leading to its inactivation. Consequently, the TGF-β signaling pathway, a major pathway for control of cell growth and differentiation, is downregulated. | INFO | |||||
| 31700 31701 | 0.1 mg 1.0 mg | NXP2NXP2, also known as MORC3, localizes to the nuclear matrix. This 140kDa protein is involved in the regulation of the tumor suppressor protein p53. NXP2 serves as a diagnostic marker for dermatomyositis (DM) as autoantibodies against this protein have been isolated from patients and found to be directly involved in pathogenesis. | INFO | |||||
| 31600 31601 | 0.1 mg 1.0 mg | SAE1/SAE2SAE1 and SAE2 form heterodimers that are involved in the posttranslational modification of proteins (sumoylation). This process regulates protein structure as well as intracellular localization of the target. SAE1/2 serves as a diagnostic marker for dermatomyositis (DM) as autoantibodies against the two proteins have been isolated from patients. | INFO | |||||
| 30000 30001 | 0.1 mg 1.0 mg | MDA5As a part of the innate immune system, the cytoplasmic melanoma differentiation-associated protein 5 (MDA5; syn. CADM 140), a member of the retinoic-acid-inducible gene-I like receptors, has a role in the recognition of viral RNAs. The expression of MDA5 can be induced by type I interferons. | INFO | |||||
Autoimmune Thyroid Diseases
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 12100 12101 | 0.1 mg 1.0 mg | Thyroid Peroxidase (TPO)The membrane protein thyroid peroxidase (TPO; syn. MSA) is a key enzyme in the synthesis of thyroid hormones and identical with the so-called “thyroid microsomal antigen”. Recombinant TPO is expressed as a soluble variant comprising the extracellular domain targeted by anti-TPO autoantibodies. | INFO | |||||
| 20100 20101 | 0.05 mg 0.5 mg | Thyroid Peroxidase (TPO) biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated TPO represents a further development of the established antigen. | INFO | |||||
| 12200 12201 | 0.1 mg 1.0 mg | Thyroglobulin (non recombinant)The dimeric glycoprotein thyroglobulin, synonym for TG, is a pivotal precursor in the synthesis of thyroid hormones and comprises up to 75% of the total protein mass of the thyroid gland. It often co-purifies with thyroid peroxidase in native “thyroid microsomal antigen preparations” and is also a target of autoantibodies. | INFO | |||||
| 20200 20201 | 0.05 mg 0.5 mg | Thyroglobulin (non rec.) biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated TG represents a further development of the established antigen. | INFO | |||||
Celiac Disease
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 15200 15201 | 0.1 mg 1.0 mg | Tissue Transglutaminase (tTG; expressed in Baculovirus/Sf9)Tissue transglutaminase (tTG; syn. TGase-2) is an ubiquitously expressed enzyme, which exerts protein deamidation and transamidation activity leading to the creation of neo-epitopes and the cross-linking of proteins, respectively. DIARECT’s tTG has been sequence modified to eliminate this cross-linking activity and to prevent covalent aggregates of tTG with host cell proteins. | INFO | |||||
| 14400 14401 | 0.1 mg 1.0 mg | Tissue Transglutaminase (tTG; expressed in E.coli)Tissue transglutaminase (tTG; syn. TGase-2) is an ubiquitously expressed enzyme, which exerts protein deamidation and transamidation activity leading to the creation of neo-epitopes and the cross-linking of proteins, respectively. DIARECT’s tTG has been sequence modified to eliminate this cross-linking activity and to prevent covalent aggregates of tTG with host cell proteins. | INFO | |||||
| 19500 19501 | 0.1 mg 1.0 mg | Gliadin (recombinant; deamidated)Gliadin describes a class storage proteins found in wheat grains. Based on its solubility, α-,β-,γ-, and ω-gliadin can be distinguished. Gliadin is a common substrate of transglutaminase, which generates neo-epitopes by deamidation of glutamine side chains. The sequence of DIARECT’s Gliadin fragment has been designed to contain these neo-epitopes. | INFO | |||||
| 31500 31501 | 0.1 mg 1.0 mg | Gliadin (non recombinant)Gliadin describes a class storage proteins found in wheat grains. Based on its solubility, α-,β-,γ-, and ω-gliadin can be distinguished. Gliadin is a common substrate of transglutaminase, which generates neo-epitopes by deamidation of glutamine side chains. | INFO | |||||
Autoimmune Hepatitis
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 31800 31801 | 0.1 mg 1.0 mg | Cytochrome P450 2D6 (LKM 1; ng)Cytochrome p450 2D6 is a cytochrome p450 mono-oxygenase that is primarily expressed in the liver and identical with the so-called liver-kidney microsome 1 (LKM 1) antigen. This enzyme localizes to the endoplasmic reticulum and is involved in the detoxification of xenobiotic substances. | INFO | |||||
| 19800 19801 | 0.1 mg 1.0 mg | Cytochrome P450 2D6 (LKM 1 hp)Cytochrome p450 2D6 is a cytochrome p450 mono-oxygenase that is primarily expressed in the liver and identical with the so-called liver-kidney microsome 1 (LKM 1) antigen. This enzyme localizes to the endoplasmic reticulum and is involved in the detoxification of xenobiotic substances. | INFO | |||||
| 36400 36401 | 0.1 mg 1.0 mg | LKM1 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric LKM 1 IgG antibody ideally paired with our LKM 1 antigen. | INFO | |||||
| 13700 13701 | 0.1 mg 1.0 mg | Formiminotransferase Cyclodeaminase (LC 1)Human formiminotransferase cyclodeamidase (FTCD) is an approximately 60 kDa, liver specific, bifunctional enzyme, involved in both histidine and folate metabolism. It is identical with the so-called liver cytosol type 1 antigen (LC 1), and has been reported to oligomerize in the cytoplasm. | INFO | |||||
| 37100 37101 | 0.1 mg 1.0 mg | LC1 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric LC1 IgG antibody ideally paired with our LC1 antigen. | INFO | |||||
| 30800 30801 | 0.1 mg 1.0 mg | SLA/LPSLA/LP is a cytosolic soluble liver antigen / liver pancreas antigen found to be specifically detected in approximately 20% of the patients with AIH. Target of anti-SLA/LP is an approximately 50 kDa UGA serine tRNA- associated protein complex, which functions in the pathway of selenoprotein synthesis in human cells. | INFO | |||||
| 36200 36201 | 0.1 mg 1.0 mg | SLA/LP humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric SLA/LP IgG antibody ideally paired with our SLA/LP antigen. | INFO | |||||
Primary Biliary Cirrhosis
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 18000 18001 | 0.1 mg 1.0 mg | M2Mitochondrial 2-oxo acid dehydrogenase multienzyme complexes play a pivotal role in the regulation of the cellular redox state. M2 is the synonym for a cellular antigen comprising the E2-subunits of distinct dehydrogenase complexes, namely PDC-E2, OGDC-E2, and BCOADC-E2. | INFO | |||||
| 17700 17701 | 0.1 mg 1.0 mg | BCOADC-E2Branched chain 2-oxo acid dehydrogenase complex (BCOADC) is a mitochondrial multienzyme complex involved in the maintenance of the cellular redox state. BCOADC-E2 is the central E2 component of this complex. | INFO | |||||
| 17800 17801 | 0.1 mg 1.0 mg | OGDC-E22-oxoglutarate dehydrogenase complex (OGDC) is a mitochondrial multienzyme complex involved in the maintenance of the cellular redox state. OGDC-E2 is the central E2 component of this complex. | INFO | |||||
| 17900 17901 | 0.1 mg 1.0 mg | PDC-E2The pyruvate dehydrogenase complex (PDC) is a mitochondrial multienzyme complex involved in the maintenance of the cellular redox state. PDC-E2 is the central E2 component of this complex. | INFO | |||||
| 37200 37201 | 0.1 mg 1.0 mg | PDC-E2 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PDC-E2 IgG antibody ideally paired with our PDC-E2 antigen. | INFO | |||||
| 18900 18901 | 0.1 mg 1.0 mg | Sp100Sp100 is a 100 kDa nuclear protein, which appears as a speckled pattern in immunofluorescence assays. The function of Sp100 is not well understood, but recent findings suggest a role in the cellular response to viral infections. | INFO | |||||
| 37000 37001 | 0.1 mg 1.0 mg | Sp100 humAb IgGCritical components in assay development are standards or positive controls. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric Sp100 IgG antibody ideally paired with our Sp100 antigen. | INFO | |||||
| 19000 19001 | 0.1 mg 1.0 mg | gp210In eukaryotic cells, transport between the cytoplasm and the nucleus occurs via the nuclear pore complex. One component of this complex, the evolutionary conserved gp210, is an integral membrane glycoprotein. | INFO | |||||
| 19400 19401 | 0.1 mg 1.0 mg | Nup62The nucleoporin Nup62 represents a major component of the nuclear pore complex that is directly involved in the regulation of molecular trafficking between the nucleus and the cytoplasm. In addition, a role in centrosome homeostasis has been reported. | INFO | |||||
ANCA Associated Diseases
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 18500 18501 | 0.1 mg 1.0 mg | Myeloperoxidase (MPO; non recombinant)Myeloperoxidase (MPO) is a heme containing enzyme of neutrophil granulocytes, which contributes to the destruction of phagocytosed microorganisms by catalyzing the conversion of hydrogen peroxide to hypochlorous acid within the phagosome. | INFO | |||||
| 18600 18601 | 0.1 mg 1.0 mg | Proteinase 3 (PR3; non recombinant)Proteinase 3 (PR3) is a serine protease stored in cytoplasmic azurophilic granules of neutrophil granulocytes, where it is involved in the degradation of microorganisms within the phagolysosomes. In addition, PR3 contributes to the destruction of pathogens in the extracellular environment. | INFO | |||||
| 19200 19201 | 0.1 mg 1.0 mg | BPI (non recombinant)Bactericidal/permeability-increasing protein (BPI) was originally identified in the azurophilic granules of neutrophil granulocytes as part of the innate immune system. It is an endogenous antibiotic protein that binds lipopolysaccharide (LPS) and kills Gram-negative bacteria. | INFO | |||||
Antiphospholipid Syndrome/ Thromboembolic Syndrome
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 14900 14901 | 0.1 mg 1.0 mg | ß2-Glycoprotein 1 (Apolipoprotein H)The glycosylated plasma protein β2-glycoprotein 1 (β2-GP1), formerly known as Apolipoprotein H (Apo H), has been shown to bind charged phospholipids, especially cardiolipin. Further, an anti-coagulant function of β2-GP1 has been described. | INFO | |||||
| 11300 11301 | 0.1 mg 1.0 mg | ß2-Glycoprotein 1 (Apo H; non recombinant; human)Glycosylated plasma protein β2-glycoprotein 1 (β2-GP1), formerly known as Apolipoprotein H (Apo H), has been shown to bind charged phospholipids, especially cardiolipin. Further, an anti-coagulant function of β2-GP1 has been described. | INFO | |||||
| 11400 11401 | 0.1 mg 1.0 mg | ß2-Glycoprotein 1 (Apo H; non recombinant; bovine)Glycosylated plasma protein β2-glycoprotein 1 (β2-GP1), formerly known as Apolipoprotein H (Apo H), has been shown to bind charged phospholipids, especially cardiolipin. Further, an anti-coagulant function of β2-GP1 has been described. | INFO | |||||
Anti-GBM Disease
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 16800 16801 | 0.1 mg 1.0 mg | Glomerular Basement Membrane (GBM; dissociated)The glomerulus represents the blood filtering unit of the kidney and contains the glomerular basement membrane (GBM), which lines the capillaries. The GBM comprises type IV collagen heterotrimers formed by the collagen alpha-3(IV) chain. DIARECT offers a recombinant minicollagen variant of this protein. | INFO | |||||
| 20700 20701 | 0.05 mg 0.5 mg | GBM biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated GBM represents a further development of the established antigen. | INFO | |||||
Diabetes Mellitus
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 31900 31901 | 0.1 mg 1.0 mg | Glutamate Decarboxylase 65 kDa (GAD65; ng)The 65kDa-enzyme glutamate decarboxylase (GAD65; ng) catalyzes the decarboxylation of glutamate to gamma-aminobutyrate (GABA). In human cells, GAD65 localizes to the vicinity of the Golgi apparatus and vesicles containing GABA. | INFO | |||||
| 13800 13801 | 0.1 mg 1.0 mg | Glutamate Decarboxylase 65 kDa (GAD65)The 65kDa-enzyme glutamate decarboxylase (GAD65) catalyzes the decarboxylation of glutamate to gamma-aminobutyrate (GABA). In human cells, GAD65 localizes to the vicinity of the Golgi apparatus and vesicles containing GABA. | INFO | |||||
| 20800 20801 | 0.05 mg 0.5 mg | GAD65 biotinylatedBinding of biotin to streptavidin is one of the strongest non-covalent interactions known in nature. This feature is used in innovative bead-based technologies to improve diagnostics by investigating multiple targests in one sample or applying standard-procedures with high throughput capability. DIARECT's biotinylated GAD65 represents a further development of the established antigen. | INFO | |||||
| 30500 30501 | 0.1 mg 1.0 mg | IA-2 (ICA 512)Insulinoma-associated protein (IA-2), also called islet cell antigen 512 (ICA 512), is a catalytically inactive protein tyrosine phosphatase (PTP)-like protein and a major target of autoimmune response in diabetes mellitus. The long C-terminal intracellular tail, harbors the majority of autoantibody epitopes. IA-2 is expressed within secretory granules in neural, neuroendocrine and pancreatic islet cells. | INFO | |||||
Pernicious Anemia
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 16700 16701 | 0.1 mg 1.0 mg | Intrinsic FactorCobalamin/vitamin B12 is essential for the formation of blood cells and DNA synthesis, and needs to be taken up with the diet. Intrinsic factor, which is secreted by the stomach, binds to vitamin B12 in the small intestine to allow its endocytosis in the ileum. | INFO | |||||
Crohn’s Disease
| Product Code | Quantity | Product Name | Downloads | Data Sheet | ||||
|---|---|---|---|---|---|---|---|---|
| 19600 19601 | 0.1 mg 1.0 mg | GP2Glycoprotein 2 (GP2) is a GPI-anchored protein abundantly produced by the pancreas, but is also expressed on intestinal membranous cells (M-cells), where it serves as a receptor for the phagocytosis of FimH+ Gram-negative bacteria to induce the mucosal immune response. Some results suggest an additional immunosuppressive and anti-inflammatory function of GP2. | INFO | |||||