HisRS

Polymyositis / Dermatomyositis

Product Code Quantity Product Name Downloads Data Sheet
12900
12901
0.1 mg
1.0 mg

Histidyl-tRNA Synthetase (Jo-1)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Histidyl-tRNA synthetase (Jo-1) is specific for the amino acid histidine.
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15600
15601
0.1 mg
1.0 mg

Threonyl-tRNA Synthetase (PL-7)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Threonyl-tRNA synthetase (PL-7) is specific for the amino acid threonine.
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36800
36801
0.1 mg
1.0 mg

PL-7 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PL-7 IgG antibody ideally paired with our PL-7 antigen.
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15700
15701
0.1 mg
1.0 mg

Alanyl-tRNA Synthetase (PL-12)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Alanyl-tRNA synthetase (PL-12) is specific for the amino acid alanine.
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36900
36901
0.1 mg
1.0 mg

PL-12 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PL-12 IgG antibody ideally paired with our PL-12 antigen.
INFO   
11100
11101
0.1 mg
1.0 mg

Glycyl-tRNA Synthetase (EJ)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Glycyl-tRNA synthetase (EJ) is specific for the amino acid glycine.
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30100
30101
0.1 mg
1.0 mg

Asparaginyl-tRNA Synthetase (KS)

For mRNA translation at the ribosomes, amino acids are covalently attached (“loaded”) onto their respective tRNAs by specific amino-acyl-tRNA synthetases. Asparaginyl-tRNA synthetase (KS) is specific for the amino acid asparagine.
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18400
18401
0.1 mg
1.0 mg

SRP54

The signal recognition particle (SRP) recruits secretory and transmembrane proteins to the endoplasmic reticulum (ER) where co-translational translocation across the ER membrane occurs. SRP54 is the SRP subunit directly binding to the N-terminal signal peptide of these proteins.
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36500
36501
0.1 mg
1.0 mg

SRP54 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric SRP54 IgG antibody ideally paired with our SRP54 antigen.
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16000
16001
0.1 mg
1.0 mg

PM/Scl 100

The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 100 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.
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17000
17001
0.1 mg
1.0 mg

PM/Scl 75

The polymyositis/scleroderma (PM/Scl) complex is the human ortholog of the Saccharomyces cerevisiae exosome, which is involved in the processing and degradation of RNAs. PM/Scl 75 is one of the human subunits found in the nucleoplasm and, at higher concentrations, in the nucleolus.
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18100
18101
0.1 mg
1.0 mg

Mi-2

The nucleosome remodeling deacetylase (NuRD) complex exerts histone deacetylase activity and functions in the regulation of gene transcription. Mi-2, a subunit of the NuRD complex, is a DNA-dependent ATPase helicase and appears to be involved in the repair of the basal epidermis.
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36700
36701
0.1 mg
1.0 mg

Mi-2 humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric Mi-2 antibody ideally paired with our Mi-2 antigen.
INFO   
11000
11001
0.1 mg
1.0 mg

TIF1 gamma

Transcriptional intermediary factor 1-gamma (TIF1 gamma), originally named p155 and synonymous for p155/140 and TRIM33, is a nuclear protein that functions as a mono-ubiquitin ligase for Smad4, a TGF-β signal transducer, leading to its inactivation. Consequently, the TGF-β signaling pathway, a major pathway for control of cell growth and differentiation, is downregulated.

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30000
30001
0.1 mg
1.0 mg

MDA5

As a part of the innate immune system, the cytoplasmic melanoma differentiation-associated protein 5 (MDA5; syn. CADM 140), a member of the retinoic-acid-inducible gene-I like receptors, has a role in the recognition of viral RNAs. The expression of MDA5 can be induced by type I interferons.
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