RNP/Sm (non recombinant; bovine)

Systemic Lupus Erythematosus

Product Code Quantity Product Name Downloads Data Sheet
17500
17501
0.1 mg
1.0 mg

Sm (non recombinant; bovine)

U-small nuclear riboprotein complexes (U-snRNPs), a pivotal component of spliceosomes, are formed between small non-coding nuclear RNAs and a protein moiety. Seven different Sm proteins aggregate into a heteroheptameric protein core, which is conserved between the different U-snRNP subclasses.
INFO   
11600
11601
0.1 mg
1.0 mg

RNP/Sm (non recombinant; bovine)

U-small nuclear riboprotein complexes (U-snRNPs), a pivotal component of spliceosomes, are formed between small non-coding nuclear RNAs and a protein moiety. While the seven Sm proteins are conserved, the proteins called RNP antigens are unique for each U-snRNP subclass.
INFO   
11700
11701
0.1 mg
1.0 mg

SmD

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD comprises equal masses of SmD1, SmD2, and SmD3. In addition, both SmD1 and SmD3 contain symmetrically dimethylated arginine residues, which represent a major epitope.
INFO   
11800
11801
0.1 mg
1.0 mg

SmD1

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. Like native SmD1, DIARECT’s recombinant SmD1 contains symmetrically dimethylated arginine residues.
INFO   
11900
11901
0.1 mg
1.0 mg

SmD2

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. SmD2 completes the list of SmD proteins offered by DIARECT.
INFO   
12000
12001
0.1 mg
1.0 mg

SmD3

In eukaryotic cells, the Sm-proteins B/B’, D1, D2, D3, E, F, and G form a heteroheptameric protein core shared between all uracil-rich small nuclear ribonucleoprotein (U-snRNP) complexes. Like native SmD3, DIARECT’s recombinant SmD3 contains symmetrically dimethylated arginine residues.
INFO   
31000
31001
0.1 mg
1.0 mg

Nucleosome (non recombinant; bovine)

Nucleosome cores are essential for DNA packaging in eukaryotes. Each core consists of an octamer including two copies of each histone 2A, 2B, 3 and 4 around which an approx. 140 bp section of DNA is wound twice. DIARECT provides native nucleosome antigens of bovine origin.
INFO   
31100
31101
0.1 mg
1.0 mg

Histone (non recombinant; bovine)

Dynamics of chromatin structure depend on posttranslational modification of histones and appearance of various histone variants. Histone H3 and H4 can be covalently modified (e.g. methylation, acetylation) at several residues. These and H2A/H2B-modifications constitute the so called histone code.
INFO   
12300
12301
0.1 mg
1.0 mg

dsDNA (plasmid)

Diarect’s double stranded DNA (dsDNA) is a circular plasmid that is propagated in and purified from Echerichia coli to eliminate potential contaminations with nuclear proteins.
INFO   
14100
14101
0.1 mg
1.0 mg

Ribosomal Phosphoprotein P0

Eukaryotic ribosomes are composed of a 40S and a 60S subunit. In the larger subunit, three acidic and phosphorylated proteins, the so-called ribosomal phosphoproteins P0-P2, have been identified. P0 is the largest phosphoprotein with a molecular weight of 38 kDa.
INFO   
14200
14201
0.1 mg
1.0 mg

Ribosomal Phosphoprotein P1

The eukaryotic 60S ribosomal subunit comprises ribosomal RNA and mostly basic proteins. In addition, three acidic and phosphorylated proteins (P0, P1, P2) have been identified. With a molecular weight of 19 kDa, P1 is the second largest ribosomal phosphoprotein.
INFO   
14300
14301
0.1 mg
1.0 mg

Ribosomal Phosphoprotein P2

The eukaryotic 60S ribosomal subunit comprises ribosomal RNA and mostly basic proteins. In addition, three acidic and phosphorylated proteins (P0, P1, P2) have been identified. With a molecular weight of 17 kDa, P2 is the smallest ribosomal phosphoprotein.
INFO   
15400
15401
0.1 mg
1.0 mg

Proliferating Cell Nuclear Antigen (PCNA)

Proliferating cell nuclear antigen (PCNA; syn. Cyclin) is a co-factor of DNA polymerase delta, forms homotrimers around double stranded DNA, and is involved in DNA replication and repair. Since its expression rate correlates with the rate of DNA replication, PCNA is a proliferation marker in basic research.
INFO
36600

0.1 mg

PCNA humAb IgG

Critical components in assay development are positive controls and calibrators for IVD kits. As an alternative to characterized disease state plasma, DIARECT provides a human chimeric PCNA IgG antibody ideally paired with our PCNA antigen.
INFO   
17300
17301
0.1 mg
1.0 mg

Ku (p70/p80)

Eukaryotic Ku is a heterodimeric DNA binding protein formed by the p70 and p80 subunits that were named according to their respective molecular weight. Ku is a key factor of the non-homologous end joining (NHEJ) DNA repair pathway by directly binding to DNA ends created at DNA double strand breaks.
INFO
19700
19701
0.1 mg
1.0 mg

Nucleolin

The phosphoprotein nucleolin primarily localizes to the nucleolus where it is involved in the regulation of rRNA gene transcription and ribosome assembly. In addition, nucleolin is also implicated in mRNA translation and turnover in the cytoplasm highlighting its multiple cellular functions.
IMFO